Mass Spectrometry Applications in Biomedical Research

Mass Spectrometry Applications in Biomedical Research

Copyright © 2015 Fa-Yun Che et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. We are so happy and excited to see our special issue published. With the tremendous advances of modern mass spectrometry (MS) techniques, MS has be...

Accelerator mass spectrometry for biomedical research.

Accelerator mass spectrometry (AMS) is the most sensitive method for detecting and quantifying rare long-lived isotopes with high precision. In this chapter, we review the principles underlying AMS-based biomedical studies, focusing on important practical considerations and experimental procedures needed for the detection and quantitation of (14)C- and (3)H-labeled compounds in various experime...

Biomedical accelerator mass spectrometry: recent applications in metabolism and pharmacokinetics.

BACKGROUND Accelerator mass spectrometry (AMS) is a sensitive isotope ratio technique used in drug development that allows for small levels of 14C-drug to be administered to humans, thereby removing regulatory hurdles associated with radiotracer studies. AMS uses innovative study designs to obtain pharmacokinetic and metabolism data. OBJECTIVE This review addresses the metabolism and pharmaco...

Practical quantitative biomedical applications of MALDI-TOF mass spectrometry.

Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOFMS) is used to obtain fast and accurate determinations of molecular mass, but quantitative determinations are generally made by other techniques. In this study we illustrate the practical utility of automated MALDI-TOFMS as a tool for quantifying a diverse array of biomolecules covering an extensive molecular...

Development of direct ionization methods for mass spectrometry – biomedical applications